Elucidating symptoms of COVID-19 illness in the Arizona CoVHORT: a longitudinal cohort study

The most commonly reported symptoms of acute COVID-19 in the Arizona CoVHORT were fatigue (82.2%), headache (74.6%), aches, pains or sore muscles (66.3%), loss of taste or smell (62.8) and cough (61.9%). COVID-19-positive participants were more likely than negative participants to experience loss of taste and smell, bone or nerve pain, headache, nausea, or diarrhea. When comparing confirmed COVID-19 cases with either confirmed negative or untested participants, the pattern of symptoms for those with SARS-CoV-2 infection are different from symptoms from other potential circulating pathogens.

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SARS-CoV-2 infection and subsequent changes in the menstrual cycle among participants in the Arizona CoVHORT Study

We observed 16% of the participants in our sample reported changes to their menstrual cycle after having a COVID-19 infection. The most commonly reported changes were: irregular menstruation (60%), increase in premenstrual syndrome symptoms (PMS) (45%), and infrequent menstruation (35%). Those participants who reported changes to their menstrual cycle were more likely to report a greater number of Covid-19 symptoms, including fatigue, headache, body aches and pains, and shortness of breath and to identify as Hispanic when compared to those who reported no changes to their menstrual cycle.

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Post-acute sequelae of COVID-19 in a non-hospitalized cohort:

Results from the Arizona CoVHORT

In this manuscript, we sought to examine the clinical presentation and duration of illness of post-acute sequelae of COVID-19 (PASC), or long-COVID, among participants of the CoVHORT who where not hospitalized for their acute SARS-CoV-2 infection. As of February 24, 2021, there were 303 participants in the CoVHORT who had reported a positive test result and having had COVID-19. Among these 303 individuals, 208 (68.7%) participants reported still experiencing at least one symptom 30 days after their COVID-19 diagnosis and were classified as having PASC, or long-COVID.

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Design of the Arizona CoVHORT: A Population-Based COVID-19 Cohort

This manuscript describes a scalable study design that utilizes a wide range of recruitment sources, leveraging electronic data collection to capture and link longitudinal participant data on the current and emerging issues associated with the COVID-19 pandemic.

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